Assay Biologist

Job Type
3 Year Fixed Term Contract, Full Time

Location
Cambridge, UK

Salary
Salary not specified

PostGraduated
PhD in a relevant biological/biochemical science

Job Description
Astex Pharmaceuticals is seeking a talented Assay Biologist to join its drug discovery bioscience group, contributing to projects from target evaluation through to candidate selection.

Working within multidisciplinary teams alongside structural biologists, biophysicists, chemists, bioinformaticians, and biologists, the successful candidate will apply expertise in enzyme and protein mechanisms to optimise fragment hits into lead compounds.

The role will involve developing and running primary assays to support compound testing against relevant drug targets. Previous experience with biochemical assays and screening formats is essential.

Skills & Experience Required
Essential Qualifications & Experience
PhD in a relevant biological/biochemical science
Experience establishing robust biochemical, cell-free assays in either industry or academia
Knowledge of biochemical assays and screening formats
Strong interpersonal and communication skills
Desirable Qualifications & Experience
Experience with enzyme kinetics, assay development, and troubleshooting
Strong analytical skills
Knowledge of chemistry and/or biophysics
Molecular biology expertise, including cloning and cell editing techniques
Experience working with target classes such as kinases, membrane proteins, and protein-protein interactions
Previous experience working within matrix teams in pharma or biotech environments

Principal Responsibilities
Design, develop, and execute de novo assays for a range of protein systems
Support drug discovery projects involving novel enzymes and protein-protein interactions
Provide mechanistic insight on targets and compounds
Collaborate with chemistry and biophysics teams to interpret SAR data
Explore and implement innovative assay technologies
Provide training and guidance to junior team members where appropriate

About the Company
Astex Pharmaceuticals is a global leader in innovative drug discovery and development. The company has successfully applied its proprietary Fragment-Based Drug Discovery platform to develop multiple clinical-stage drug candidates.

Collaborations with pharmaceutical partners have resulted in approved oncology therapies partnered with Novartis, Janssen, and AstraZeneca. Astex continues to expand its research focus in Oncology and Neurological Disorders.

Astex offers:

Competitive salary and benefits package
Hybrid working opportunities
Training and career development support
Inclusive and diverse working environment
The company is based at the Cambridge Science Park, with excellent transport links and onsite facilities.

How to Apply
Applicants should apply by email to [email protected] and attach:

CV
Cover letter (PDF format)
Please include the reference:
ASBI/0426

If sponsorship is required, candidates should state this in their application email.

Closing Date
25th May 2026